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目的探讨5-羟甲基胞嘧啶(5hm C)在膀胱尿路上皮癌(UC)的表达情况以及临床意义。方法采用免疫组织化学染色检测21例手术切除UC组织及癌旁尿路上皮组织中5hm C的表达情况。随后检测92例临床资料完善的手术切除UC组织中5hm C的表达情况,采用非参数Mann-Whitney U检验分析5hm C的表达和临床资料间的相关性,采用Kaplan-Meier检验进行单因素生存分析。结果 5hm C在癌旁尿路上皮组织和UC组织中的表达具有显著性差异,而5hm C在低级别和高级别的UC组织中,以及在TNM分级中的表达无明显差别。Kaplan-Meier单因素生存分析结果表明,5hm C表达水平分别与UC患者的生存率及无复发率无显著相关性。结论 UC组织中5hm C的表达水平明显下调,5hm C与UC的进展、预后和复发无相关性。
Objective To investigate the expression and clinical significance of 5-hydroxymethylcytosine (5hm C) in bladder urothelial carcinoma (UC). Methods Immunohistochemical staining was used to detect the expression of 5hm C in 21 cases of resected UC tissues and adjacent non-cancerous urothelial tissues. Subsequently, the expression of 5hm C in 92 surgically resected UC tissues was detected. The correlation between 5hm C expression and clinical data was analyzed by using non-parametric Mann-Whitney U test. The Kaplan-Meier test was used to analyze the univariate survival analysis . Results The expression of 5hm C in adjacent non-cancerous urothelial tissues and UC tissues was significantly different. However, there was no significant difference in the expression of 5hm C between low-grade and high-grade UC tissues and TNM grade. Kaplan-Meier univariate survival analysis showed that 5hm C expression levels were not associated with the survival rate of UC patients and no recurrence rate was not significantly correlated. Conclusions The expression level of 5hm C in UC tissues was significantly down-regulated. There was no correlation between 5hm C and UC progression, prognosis and recurrence.