Receptor activity-modulating proteins(RAMPs)are accessory molecules that form com-plexes with specific G protein-coupled receptors(GPCRs)and modulate their functions.It is established that RAMP interacts with the glucagon receptor family of GPCRs but the
Non-small cell lung cancer is recognized as the deadliest cancer across the globe.In some areas,it is more common in women than even breast and cervical cancer.Its rise,vaulted by smoking habits and increasing air pollution,has garnered much attention and
Compounds that selectively modulate multiple targets can provide clinical benefits and are an alternative to traditional highly selective agents for unique targets.High-throughput screening(HTS)for multitarget-directed ligands(MTDLs)using approved drugs,a
Idiosyncratic drug-induced liver injury(iDILI)encompasses the unexpected harms that pre-scription and non-prescription drugs,herbal and dietary supplements can cause to the liver.iDILI remains a major public health problem and a major cause of drug attrit
Sulfonylureas are widely used oral anti-diabetic drugs.However,its long-term usage effects on patients\'lifespan remain controversial,with no reports of influence on animal longevity.Hence,the anti-aging effects of chlorpropamide along with glimepiride,
Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths,char-acterized by highly hypoxic tumor microenvironment.Hypoxia-inducible factor-1α(HIF-1α)is a major regulator involved in cellular response to changes of oxygen levels,su
The immune checkpoints,cytotoxic T-lymphocyte-associated antigen 4(CTLA-4)and pro-grammed cell death protein-1/ligand-1(PD-1/PD-L1)are vital contributors to immune regulation and toler-ance.Recently immune checkpoint inhibitors(ICIs)have revolutionized ca
During the traumatic brain injury(TBI),improved expression of circulatory miR-21 serves as a diagnostic feature.Low levels of exosome-miR-21 in the brain can effectively improve neuroinflamma-tion and blood—brain barrier(BBB)permeability,reduce nerve apop
Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhib