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目的探讨小剂量米索前列醇用于无痛人工流产术的临床效果。方法选取2013年3月—2014年3月中国人民解放军第一八四医院收治的120例要求无痛人工流产终止妊娠的健康妇女,分为对照组和观察组,每组60例。观察组于术前2h应用小剂量米索前列醇,对照组术前不应用任何扩张宫颈的药物。比较两组术中宫颈扩张情况、术中出血量、手术时间及预后效果。结果观察组患者宫颈扩张总有效率高于对照组,差异有统计学意义(P<0.05)。观察组术中出血量为(20.0±3.1)ml,对照组为(23.0±8.5)ml;观察组手术时间为(2.5±1.0)h,对照组为(3.6±1.4)h。两组术中出血量及手术时间比较,差异有统计学意义(P<0.05)。观察组术前1h阴道内出现血性分泌物,对照组无。术后,观察组1例出现腹痛,但可耐受,1例出现恶心;对照组无。结论小剂量米索前列醇用于无痛人工流产术松弛宫颈的作用明显,有助于减少术中出血量及缩短手术时间。
Objective To investigate the clinical effect of low dose misoprostol for painless artificial abortion. Methods From March 2013 to March 2014, 120 healthy women with painless induced abortion termination were enrolled in the 184th Hospital of People’s Liberation Army of China. They were divided into control group and observation group, 60 cases in each group. The observation group was treated with low-dose misoprostol 2 hours before operation, and the control group did not use any drugs for expanding the cervix before operation. Intraoperative cervical dilatation, intraoperative blood loss, operation time and prognosis were compared between the two groups. Results The total effective rate of cervical dilatation in observation group was higher than that in control group, the difference was statistically significant (P <0.05). In the observation group, the intraoperative blood loss was (20.0 ± 3.1) ml in the control group (23.0 ± 8.5) ml; in the observation group, the operation time was (2.5 ± 1.0) h in the observation group and (3.6 ± 1.4) h in the control group. The two groups of intraoperative blood loss and operative time, the difference was statistically significant (P <0.05). Observation group 1h preoperative bloody vaginal discharge, the control group without. One patient in the observation group had abdominal pain after surgery but was tolerated and one patient showed nausea. None in the control group. Conclusion The use of low-dose misoprostol for painless artificial abortion has a significant effect on relaxing the cervix, helping to reduce intraoperative blood loss and shorten the operation time.