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胰多肽(Pancreatic Polypeptide)、胰高血糖素(Glucagon)和胰岛素一样,也产生于胰腺内分泌细胞。胰多肽具有多种药理作用,如分解糖原,促进胃液分泌,抑制胰腺水、重碳酸盐和蛋白质分泌。胰高血糖素主要具有抑制胃液和胰液分泌,促进胆汁分泌,增强心肌收缩力等生物学效应,临床上可用于治疗低血糖、心源性休克、心力衰竭和食道痉挛等。这两种多肽激素已引起人们广泛重视。1968年,Kimmel等首先从制备胰岛素的副产物中分离了胰多肽,随后,Pollock及其同
Pancreatic Polypeptide, Glucagon and insulin are also produced in pancreatic endocrine cells. Pancreatic peptides have a variety of pharmacological effects, such as the decomposition of glycogen, promote gastric secretion, inhibition of pancreatic water, bicarbonate and protein secretion. Glucagon mainly inhibits the secretion of gastric juice and pancreatic juice, promote bile secretion, enhance myocardial contractility and other biological effects, clinically useful for the treatment of hypoglycemia, cardiogenic shock, heart failure and esophageal spasm. These two polypeptide hormones have aroused widespread attention. In 1968 Kimmel et al. First isolated pancreatic polypeptide from by-products of insulin preparation, and subsequently, Pollock and its