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目的:观察小剂量沙利度胺加地塞米松治疗多发性骨髓瘤的疗效。方法:低剂量沙利度胺加治疗多发性骨髓瘤25例。治疗方法用沙利度胺初始剂量100-200mg/d,晚上一次口服,每28天为一个周期,共3个周期,地塞米松给予15mg/d口服,第1-4天,15-18天,每28天为1个周期,至少治疗3个周期。结果:部分缓解15例,进步7例,无效3例。结论:小剂量沙利度胺加地塞米松治疗多发性骨髓瘤安全、有效,不良反应少。
Objective: To observe the curative effect of low dose thalidomide and dexamethasone on multiple myeloma. Methods: 25 cases of multiple myeloma were treated with low dose thalidomide. Treatment with thalidomide initial dose of 100-200mg / d, once every night, every 28 days for a period of three cycles, dexamethasone given 15mg / d orally, 1-4 days, 15-18 days , Every 28 days for a period of at least three cycles of treatment. Results: Partial relief in 15 cases, progress in 7 cases, 3 cases. Conclusion: The low dose thalidomide combined with dexamethasone in the treatment of multiple myeloma is safe, effective and less adverse reactions.