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GW112是近年来发现的嗅觉介导素相关蛋白家族的新成员,在神经发育、细胞间黏附、细胞周期调控及肿瘤发生等多种细胞功能中起重要作用。GW112调节肿瘤细胞增殖、凋亡、黏附,并对关键信号转导通路起调控作用。GW112在消化道肿瘤中异常表达,且在早期胃癌及结直肠癌中呈高度特异性表达,提示其可能成为新的早期诊断胃癌及结直肠癌的靶点基因。
GW112 is a new member of the olfactory mediator-related protein family found in recent years and plays an important role in various cellular functions such as neurodevelopment, cell adhesion, cell cycle regulation and tumorigenesis. GW112 regulates tumor cell proliferation, apoptosis, adhesion and regulates key signal transduction pathways. GW112 is abnormally expressed in gastrointestinal tumors and highly expressed in early stage gastric cancer and colorectal cancer, suggesting that GW112 may become a new target gene for early diagnosis of gastric cancer and colorectal cancer.