妊娠特异性β_1糖蛋白(SP1)是胎盘滋养层细胞分泌的一种蛋白,含量随孕周增加而增高,患产科某些疾病时则明显下降.为观察正常和病理妊娠母血SP1的动态变化,作者用放免法测定153名孕妇静脉血SP1浓度,从112名正常妊娠8～40周的妇女采取514份血清进行观测.正常妊娠是指临床证实新生儿健康、足月产、体重在2,500g以上、无胎儿窒息、胎盘形态学 Pregnancy-specific β_1 glycoprotein (SP1) is a protein secreted by placental trophoblast cells, the content increased with gestational age increased, and obstetrics certain diseases decreased significantly. To observe the dynamic changes of normal and pathological gestational maternal serum SP1 , The author used radioimmunoassay to measure the serum concentration of SP1 in 153 pregnant women and took 514 serum samples from 112 women with normal pregnancy from 8 to 40 weeks.Normal pregnancy refers to the clinical confirmed neonatal health and full-term birth weight at 2,500g Above, no fetal suffocation, placental morphology