论文部分内容阅读
目的探讨甲基强的松龙(MP)冲击治疗儿童过敏性紫癜(HSP)的临床疗效。方法 HSP患儿40例随机分为两组:对照组18例,给予常规治疗,包括抗组胺及防治感染等治疗;治疗组22例,在常规治疗基础上加用MP冲击治疗:输注MP 5-15mg·kg-1·d-1,连用3d后口服强的松,并于1周内减量渐停。应用ELISA双抗体夹心法检测治疗前后血清IL-6和IL-8表达;比较两组疗效。结果治疗组皮疹、腹痛、消化道症状和关节肿痛消失以及肾损害恢复时间均短于对照组(P<0.05或P<0.01);治疗后,治疗组血清IL-6和IL-8水平低于对照组[(12.02±4.81)ng/ml vs.(17.31±8.47)ng/ml和(10.61±4.66)ng/ml vs.(14.74±5.20)ng/ml](P<0.05)。结论早期应用MP冲击治疗儿童过敏性紫癜安全、有效。
Objective To investigate the clinical efficacy of methylprednisolone (MP) shock in the treatment of Henoch - Schonlein purpura (HSP) in children. Methods Forty children with HSP were randomly divided into two groups: control group (n = 18), routine treatment including antihistamine and anti-infection treatment, and treatment group (n = 22). MP treatment was given on the basis of routine treatment: 5-15mg · kg-1 · d-1, even 3d after oral prednisone, and within 1 week reduction gradually stop. Serum IL-6 and IL-8 levels were detected by ELISA double antibody sandwich method before and after treatment. The curative effect was compared between the two groups. Results The rash, abdominal pain, disappearance of gastrointestinal symptoms and joint swelling and pain and recovery time of renal damage in the treatment group were shorter than those in the control group (P <0.05 or P <0.01). After treatment, the levels of IL-6 and IL-8 (12.02 ± 4.81) ng / ml vs. (17.31 ± 8.47) ng / ml and (10.61 ± 4.66) ng / ml vs. (14.74 ± 5.20) ng / ml] (P <0.05) in the control group. Conclusion Early application of MP shock treatment of allergic purpura in children is safe and effective.