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目的研究男性肾移植患者术后勃起功能障碍(ED)的相关影响因素。方法随机选择25～57岁、术后半年以上、血肌酐133μmol/L以下的已婚男性肾移植受者50例,采用勃起功能国际问卷(IIEF-5)对其肾移植前后勃起功能进行评估,并应用多因素Logistic回归分析,确定对勃起功能有影响的相关因素。结果肾移植术前有41例(82%)被诊断为不同程度的ED,移植术后26例被确定为ED(52%),术前与术后比较差异有统计学意义(P<0.05)。Logistic回归分析表明,年龄、血液透析时间、移植肾动脉吻合方式和以环孢素(CsA)为基础的免疫抑制剂治疗是影响勃起功能的独立和显著因素(P<0.05),相对危险度分别为3.06、2.03、3.93、2.74。结论成功的肾移植术可改善患者的勃起功能,但仍有着较高的ED发生率,年龄、血液透析时间、术中移植肾动脉吻合方式、以CsA为基础的免疫抑制剂治疗是影响勃起功能的主要因素。
Objective To study the related factors of postoperative erectile dysfunction (ED) in male renal transplant recipients. Methods Fifty male patients with renal transplant recipients aged 25 to 57 years and more than half a year after operation and with serum creatinine below 133μmol / L were enrolled in this study. Erectile function before and after renal transplantation was assessed using the International Erectile Function Questionnaire (IIEF-5) Multivariate Logistic regression analysis was used to determine the relevant factors that had an impact on erectile function. Results Before transplantation, 41 cases (82%) were diagnosed as ED with different degrees, and 26 cases after transplantation were identified as ED (52%). The difference between before and after operation was statistically significant (P <0.05) . Logistic regression analysis showed that age, hemodialysis time, renal graft anastomosis and cyclosporin (CsA) -based immunosuppressive therapy were independent and significant factors (P <0.05), respectively, with relative risk 3.06, 2.03, 3.93, 2.74. Conclusions Successful renal transplantation can improve the erectile function of patients, but there is still a high incidence of ED, age, hemodialysis time, intraoperative transplantation of renal artery anastomosis, CsA-based immunosuppressive therapy is the impact of erectile function The main factor.