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目的;研究表柔比星(Epi)在肿瘤患者体内的药物动力学.方法:11例肿瘤患者单次iv 60mg/m~2Epi,用HPLC测定Epi血药浓度,数据用3P87药物动力学程序进行模型拟合并计算药物动力学参数.结果:Epi的药-时曲线符合三室模型,其主要药物动力学参数分别为:T_(1/2p)=(0.052±0.018)h,T_(1/2(?))=(1.25±1.18)h,T_(1/2p)=(31.1±13.7)h,Vc=(23.9±11.2)ml,AUC=(2009±429)ng·h/ml,CL=(50.1±12.1)ml/h.结论:Epi在肿瘤患者体内分布迅速,消除缓慢.
Objective: To study the pharmacokinetics of epirubicin (Epi) in patients with cancer.Methods: A single iv 60 mg / m ~ 2Epi in 11 patients with cancer was used to determine the plasma concentration of Epi by HPLC. The data were analyzed by 3P87 pharmacokinetic program Model fitted and calculated pharmacokinetic parameters.Results: The drug-time curve of Epi accorded with the three-compartment model and its main pharmacokinetic parameters were: T 1 / 2p = 0.052 ± 0.018 h, T 1/2, Tc (1 / 2p) = (31.1 ± 13.7) h, Vc = (23.9 ± 11.2) ml, AUC = (2009 ± 429) ng · h / ml, CL = (50.1 ± 12.1) ml / h.Conclusion: Epi is rapidly distributed and slowly eliminated in tumor patients.