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败血症时输入粒细胞,其疗效已经动物试验及临床研究予以肯定。由于临床和输入方法上的困难,以致治疗应用受限。粒细胞系总数约为100～250×10~8/kg,其中一半在骨髓内,可从一健康的粒细胞供者血中获取粒细胞9～16×10~8/kg/d。粒细胞在血中的生物学半寿期为6～7h,在组织中则2～3d仍具吞噬功能。血管系中的粒细胞约7×10~8/kg(40％)处于循环状态,而60％则在脾和附于毛细血管壁及小静脉壁上。从供者血中获取粒细胞2～8×10~8/kg时,即可发生粒细胞分布的迅速改变,而不致使循环血中的粒细胞减少。
The input of granulocytes in sepsis has been affirmed by animal experiments and clinical studies. Due to clinical and input methodological difficulties, therapeutic applications are limited. The total number of granulocytic lines is about 100-250 × 10-8 / kg, half of them are in the bone marrow, and the granulocytes can be obtained from a healthy granulocyte donor blood of 9-16 × 10-8 / kg / d. The biological half-life of granulocytes in the blood is 6 ~ 7h, 2 ~ 3d in the tissue is still phagocytic function. Granulocytes in the vascular line are about 7 × 10 ~ 8 / kg (40%) in circulation, while 60% are in the spleen and attached to the capillary wall and venule wall. When granulocytes are obtained from a donor blood at 2 to 8 × 10 -8 / kg, rapid changes in the distribution of the granulocytes can occur without reducing the number of neutrophils in the circulating blood.