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目的评价5%咪喹莫特乳膏治疗儿童寻常疣的临床疗效和安全性。方法将入选的86例寻常疣患儿按照随机数字表分成两组。治疗组(39例)每晚睡前予5%咪喹莫特乳膏外搽,6~10h后清洗患处皮肤,每周连续用5d,停用2d为1个疗程。对照组(47例)予液氮冷冻治疗。两组患者疗程均为12周。结果治疗12周后,治疗组有效率为64.10%,对照组有效率为80.85%,差异无统计学意义(P>0.05)。治疗过程中,治疗组不良反应发生率为25.64%,对照组不良反应发生率为89.36%,差异有统计学意义(P<0.01)。治疗组复发率为8.00%,对照组复发率为26.32%,差异无统计学意义(P>0.05)。结论 5%咪喹莫特乳膏治疗儿童寻常疣安全有效,不良反应少。
Objective To evaluate the clinical efficacy and safety of 5% imiquimod cream in the treatment of children with verruca vulgaris. Methods 86 cases of children with unusual warts were divided into two groups according to random number table. The treatment group (39 cases) was given 5% imiquimod cream before going to bed every night. The skin of the affected area was cleaned after 6 ~ 10 hours, and continued for 5 days every week. The control group (47 cases) was treated with liquid nitrogen freezing. Two groups of patients were treated for 12 weeks. Results After 12 weeks of treatment, the effective rate was 64.10% in the treatment group and 80.85% in the control group, with no significant difference (P> 0.05). The incidence of adverse reactions in the treatment group was 25.64%, while that in the control group was 89.36%, the difference was statistically significant (P <0.01). The recurrence rate was 8.00% in the treatment group and 26.32% in the control group, with no significant difference (P> 0.05). Conclusions 5% imiquimod cream is safe and effective in the treatment of children with verruca vulgaris, with few adverse reactions.