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蝎毒及其提取物有明显的镇痛作用，我们对其中枢镇痛作用效果与吗啡进行了比较。向大鼠中脑导水管周围灰质（PAG）内微量注射蝎毒（scorpionvenom，SV）和吗啡（morphine），以热辐射甩尾法为指标，观察比较二者中枢镇痛作用效果。结果表明：向大鼠PAG内恒速注射0．025％～0．10％SV0．5μL（相当于0．5μg／kg～2μg／kg）即出现痛阈升高，20min达峰值（痛阈最大提高150％以上），与对照组比较有显著差异（P＜0．01），而欲使大鼠痛阈提高150％，PAG内注射吗啡的用量约为10μg／kg。提示SV有很强的中枢镇痛作用，作用强于吗啡4倍以上。
The scorpion venom and its extracts have obvious analgesic effects. We compared the effect of nausea and morphine on the central analgesic effect. Scolonvenom (SV) and morphine were injected into the periaqueductal gray (PAG) of the rat’s midbrain, and the effect of central analgesia was observed and compared by using the thermal radiation flick method as an indicator. The results showed that the constant increase of the pain threshold occurred at a constant rate of 0.025% to 0.10% SV 0.5 μL (corresponding to 0.5 μg/kg to 2 μg/kg) in rat PAG, and peaked at 20 min (maximal pain threshold). Increased by more than 150%), compared with the control group was significantly different (P <0.01), and to increase the pain threshold of rats by 150%, the amount of morphine injected into the PAG is about 10μg/kg. It is suggested that SV has a strong central analgesic effect and is stronger than morphine by more than 4 times.