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目的观察慢性活动性乙型肝炎（ＣＡＨ）中型、重型及重型伴活动性肝硬变患者血清的肿瘤坏死因子（ＴＮＦ）、可溶性白介素－２受体（ｓＩＬ－２Ｒ）含量及外周血淋巴细胞亚群变化与肝组织病变的关系。方法肝细胞生长素（ｐＨＧＦ）８０ｍｇ，静脉滴注１日１次，２个月一个疗程。治疗前后检测与肝组织活检同步的外周血ＴＮＦ、ｓＩＬ－２Ｒ及淋巴细胞亚群。结果ｐＨＧＦ在显著改善肝组织病变的同时，能显著降低外周血ＴＮＦ、ｓＩＬ－２Ｒ含量及显著增加淋巴细胞亚群的比例（Ｐ＜０．０１）。说明血清ＴＮＦ、ｓＩＬ－２Ｒ含量及外周血淋巴细胞亚群的比例与慢性乙肝的肝组织病变之间存在着动态关系。结论血清ＴＮＦ、ｓＩＬ－２Ｒ含量及外周血淋巴细胞亚群的比例与慢性乙肝的肝组织病变有关。
Objective To investigate the changes of serum tumor necrosis factor (TNF), soluble interleukin-2 receptor (sIL-2R) and peripheral blood lymphocyte subsets in patients with active cirrhosis of chronic active hepatitis B (CAH) Relationship between group changes and liver lesions. Methods Hepatocyte growth factor (pHGF) 80mg, intravenous drip on the 1st 1, 2 months a course of treatment. Peripheral blood TNF, sIL-2R and lymphocyte subsets synchronized with liver biopsy were detected before and after treatment. Results Compared with the control group, pHGF significantly reduced the levels of TNF and sIL-2R in peripheral blood and significantly increased the proportion of lymphocyte subsets (P <0.01). Description of serum TNF, sIL-2R levels and peripheral blood lymphocyte subsets and chronic hepatitis B liver tissue there is a dynamic relationship between the disease. Conclusion Serum TNF, sIL-2R levels and peripheral blood lymphocyte subsets of the proportion of chronic hepatitis B liver tissue disease.