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革兰阳性菌脓毒症和葡萄球菌中毒性休克综合征(TSS)都伴有细胞因子的大量表达。血液内的脂磷壁酸(LTA)、肽聚糖(PG)等胞壁成分与毒性休克综合征毒素-1(TSST-1)、葡萄球菌肠毒素B(SEB)等超抗原成分被认为是这两种疾病中细胞因子的主要诱导剂。过去认为,上述成分通过刺激细胞产生h18、IL-12,从而进一步诱导了IFN-γ的表达。为了解葡萄球菌本身及其组分(LTA、PG、TSST-1、SEB)诱导IFN-γ表达的特点,本文作者在正常人
Gram-positive sepsis and staphylococcal toxic shock syndrome (TSS) are accompanied by the expression of cytokines. Blood components such as lipoteichoic acid (LTA), peptidoglycan (PG), and other superantigen components such as TSST-1 and SEB were considered as The main inducer of cytokines in both diseases. In the past, the above-mentioned components further induce the expression of IFN-γ by stimulating cells to produce h18 and IL-12. In order to understand the characteristics of Staphylococcus aureus itself and its components (LTA, PG, TSST-1, SEB) induced IFN-γ expression, the author in normal