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目的探讨hOGG1 Ser326Cys基因多态与原发性肝癌的关系。方法采用Meta分析对1994年1月至2009年11月国内外关于hOGG1 Ser326Cys基因多态与原发性肝癌关系的病例对照研究进行综合定量分析。结果共收集相关文献4篇,累计病例970例,对照991例。剔除日本人群数据后,hOGG1突变基因型(Cys/Cys+Ser/Cys)及突变纯合子基因型(Cys/Cys)与野生纯合子(Ser/Ser)比较,罹患肝癌的危险性均增高,合并的OR值分别为OR=1.89(1.47,2.41)和OR=2.32(1.06,5.06)。结论 hOGG1 Ser326Cys基因多态性与原发性肝癌易感性可能有关。
Objective To investigate the relationship between hOGG1 Ser326Cys polymorphism and primary liver cancer. Methods Meta-analysis was used to conduct a comprehensive quantitative analysis of the case-control study on the relationship between hOGG1 Ser326Cys polymorphism and primary hepatocellular carcinoma from January 1994 to November 2009 at home and abroad. Results A total of 4 articles were collected, with a total of 970 cases and 991 cases of controls. Compared with the wild homozygotes (Ser / Ser), hOGG1 mutant genotypes (Cys / Cys + Ser / Cys) and mutant homozygote (Cys / Cys) were higher in patients with HCC, The OR values were OR = 1.89 (1.47,2.41) and OR = 2.32 (1.06,5.06) respectively. Conclusion The hOGG1 Ser326Cys gene polymorphism may be related to the susceptibility to primary liver cancer.