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目的:探讨乙肝相关性肝癌患者经导管肝动脉化疗栓塞术(TACE)后疼痛程度的相关影响因素。方法:选取182例经TACE术的乙肝相关性肝癌患者,采用视觉模拟评分法(VAS)评分标准对每例患者疼痛程度进行评分并分为4级:0级:0分;1级:1-3分;2级:4-6分;3级:7-10分。结果:经过对患者病例资料与TACE术后疼痛程度的分析比较,发现术前HBV DNA定量结果、糖尿病史以及饮酒史与患者TACE术后疼痛程度正相关,体质指数(BMI)、肝功能Child分级与术后疼痛程度负相关,而性别、年龄、AFP浓度、高血压史及吸烟史与TACE术后疼痛程度未见明显相关性。结论:乙肝相关性肝癌患者TACE术后疼痛程度可能主要与肝功能相关,因此要对行TACE术的患者积极进行保肝护肝治疗,从而预防或降低术后疼痛程度。
Objective: To investigate the influencing factors of the pain degree after transcatheter arterial chemoembolization (TACE) in patients with hepatitis B-related liver cancer. Methods: Totally 182 patients with hepatocellular carcinoma of the liver associated with TACE were enrolled. The pain scores of each patient were scored according to the visual analogue scale (VAS) score and divided into 4 grades: 0 grade: 0 grade; grade 1: 1- 3 points; Level 2: 4-6 points; Level 3: 7-10 points. Results: The results of preoperative HBV DNA quantification, history of diabetes mellitus and alcohol consumption were positively correlated with the degree of pain after TACE. The body mass index (BMI), Child classification of liver function Negatively correlated with the degree of postoperative pain, while gender, age, AFP concentration, history of hypertension and smoking history had no significant correlation with the degree of postoperative TACE pain. Conclusion: The degree of post-TACE pain in patients with HBV-related hepatocellular carcinoma may be mainly related to liver function. Therefore, patients with TACE should be actively treated with hepatoprotective drugs to prevent or reduce postoperative pain.