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目的分析螺内酯治疗原发性醛固酮增多症的临床应用效果。方法将2016年4月~2017年2月160例原发性醛固酮增多症患者根据数字随机表法分两组各80例。常规组采用贝那普利治疗,研究组在常规组基础上给予螺内酯治疗。比较两组原发性醛固酮增多症干预效果;血压恢复正常时间、症状消失时间、心电监测正常时间;干预前后患者左室不同状态内径、射血情况、6分钟步行距离。结果研究组原发性醛固酮增多症干预效果高于常规组,P<0.05;研究组血压恢复正常时间、症状消失时间、心电监测正常时间短于常规组,P<0.05;干预前两组左室不同状态内径、射血情况、6分钟步行距离相近,P>0.05;出院时研究组左室不同状态内径、射血情况、6分钟步行距离优于常规组,P<0.05。结论螺内酯治疗原发性醛固酮增多症的临床应用效果确切,可有效加速症状消退,改善患者心功能,降低血压,值得推广。
Objective To analyze the clinical effect of spironolactone in the treatment of primary aldosteronism. Methods From April 2016 to February 2017, 160 patients with primary aldosteronism were divided into two groups according to the digital random table method, 80 cases each. The conventional group was treated with benazepril, and the study group was treated with spironolactone on the basis of conventional group. The interventional effects of primary aldosteronism were compared between the two groups. The time of recovery of blood pressure, the disappearance of symptoms, the normal time of ECG monitoring, the diameter of the left ventricle before and after intervention, the ejection of blood and the distance of 6 minutes walking were compared. Results The intervention effect of primary aldosteronism in the study group was higher than that in the conventional group (P <0.05). The time of normal blood pressure recovery, the disappearance of symptoms and the normal ECG monitoring time in the study group were shorter than those in the conventional group (P <0.05) There was no significant difference between the two groups (P> 0.05). The diameter, ejection and 6-minute walking distance of different states were similar (P> 0.05). Conclusion Spironolactone treatment of primary aldosteronism clinical application of the exact effect can effectively accelerate the symptoms subsided to improve the patient’s cardiac function, lower blood pressure, it is worth promoting.