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目的:研究神经生长因子在急性颅脑损伤中的治疗效果及对神经功能的影响。方法:选取2014年8月至2015年7月本院收治的82例急性颅脑损伤患者,随机分为观察组和对照组,每组41例。对照组采取常规对症治疗,观察组在对照组基础上采用神经生长因子治疗。观察并比较两组患者治疗前后血清S100β,白介素-6(IL-6),髓鞘碱性蛋白(MBP)及神经元特异性烯醇化酶(NSE)水平的变化情况以及临床疗效。结果:观察组总有效率高于对照组,差异具有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后血清S100β及IL-6水平均降低,差异具有统计学意义(P<0.05);与对照组比较,观察组患者治疗后血清S100β及IL-6水平较低,差异具有统计学意义(P<0.05);与治疗前比较,两组患者治疗后血清MBP及NSE水平均降低,差异具有统计学意义(P<0.05);与对照组比较,观察组患者治疗后血清MBP及NSE水平较低,差异具有统计学意义(P<0.05)。结论:神经生长因子治疗急性颅脑损伤的效果显著,能够改善患者免疫功能和神经功能,值得临床推广应用。
Objective: To study the therapeutic effect of nerve growth factor (NGF) in acute craniocerebral injury and its effect on neurological function. Methods: A total of 82 acute craniocerebral injury patients admitted to our hospital from August 2014 to July 2015 were randomly divided into observation group and control group, with 41 cases in each group. Control group to take conventional symptomatic treatment, the observation group in the control group based on the use of nerve growth factor therapy. To observe and compare the changes of serum S100β, IL-6, MBP and NSE before and after treatment in both groups and the clinical curative effect. Results: The total effective rate in the observation group was higher than that in the control group, with statistical significance (P <0.05). Compared with those before treatment, the levels of S100β and IL-6 in both groups decreased after treatment, the difference was statistically significant (P <0.05). Compared with the control group, the levels of S100β and IL-6 in the observation group were lower , The difference was statistically significant (P <0.05); compared with before treatment, serum MBP and NSE levels decreased after treatment in both groups, the difference was statistically significant (P <0.05); compared with the control group, the observation group patients treatment After the serum MBP and NSE levels were lower, the difference was statistically significant (P <0.05). Conclusion: NGF is effective in treating acute craniocerebral injury, which can improve the immune function and neurological function of patients and is worthy of clinical application.