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神经白细胞素(neuroleukin,NLK)是一种分子量为56KD 的神经营养因子,开始认为它是由去神经化的大鼠肌细胞分泌,现确认它广泛存在于肌肉、脑、心和肾等组织器官。它能维持胚胎棘神经元、骨骼肌运动神经元和感觉神经元的生长。新近研究发现,NLK 电是一种凝集素刺激 T 细胞后产生的淋巴因子产物,它还能诱导培养的人外周血单个核细胞分泌免疫球蛋白。目前,小鼠 NLK 已克隆成功,它的全棱苷酸序列也已明确,其 cDNA 已能在猴 COS-I 细胞中稳定表达。
Neurokelukin (NLK), a 56 kD molecular neurotrophic factor, was initially thought to be secreted by denervated rat myocytes and is now widely found in tissues and organs such as muscle, brain, heart and kidney . It maintains the growth of embryonic spine neurons, skeletal motor and sensory neurons. Recent studies have found that NLK is a lectin product produced after lectin stimulates T cells and induces the secretion of immunoglobulins by cultured human peripheral blood mononuclear cells. At present, mouse NLK has been cloned successfully, and its full nucleotide sequence has also been confirmed. The cDNA has been stably expressed in monkey COS-I cells.