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用雄性断乳ｗｉｓｔａｒ大鼠研究了不同水平锌、铜对大鼠血脂水平的影响。结果显示：绝对或相对铜缺乏均引起血清胆固醇、甘油三酯浓度升高；而绝对或相对锌缺乏则主要引起高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）和ＨＤＬ＿２－Ｃ浓度下降。相关分析表明：血清锌与ＨＤＬ－Ｃ、ＨＤＬ＿２－Ｃ呈明显正相关；血清铜与血清胆固醇、甘油三酯呈显著负相关。病理检查显示：除对照组外，其它各组主动脉组织形态均发生不同程度的病理改变，尤以高锌低铜、高铜低锌及低锌低铜组为著。提示在保持适宜铜水平的前提下，补充适量的锌以提高血清ＨＤＬ－Ｃ水平，可预防或延缓高脂血症的发生。
Effects of different levels of zinc and copper on blood lipid levels in rats were studied with male weanling wistar rats. The results showed that either absolute or relative copper deficiency caused elevated levels of serum cholesterol and triglycerides, whereas absolute or relative zinc deficiency caused mainly decreases in the concentrations of high-density lipoprotein cholesterol (HDL-C) and HDL-2-C. Correlation analysis showed that there was a significant positive correlation between serum zinc and HDL-C and HDL-C, serum copper and serum cholesterol and triglyceride showed a significant negative correlation. Pathological examination showed that in addition to the control group, the morphology of the aorta of the other groups all had different degrees of pathological changes, especially the high zinc and low copper, high copper and low zinc and low zinc and low copper groups. Tip to maintain the appropriate level of copper under the premise of the appropriate amount of zinc to increase serum levels of HDL-C, can prevent or delay the occurrence of hyperlipidemia.