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目的研究芸香甙在兔体内的药代动力学。方法家兔一次静注芸香甙５ｍｇ·ｋｇ－１后，利用荧光分光光度法测定不同时间的血药浓度。应用３Ｐ８７药动学软件程序对数据进行计算机处理。结果芸香甙的药时（Ｃ－Ｔ）方程为：Ｃ＝８５．９７８９ｅ－０．９０４４Ｔ＋３４．５１０５ｅ－０．０５８７Ｔ＋４．３８３８ｅ－０．００４６Ｔ。芸香甙的主要药代动力学参数如下：Ｔ１／２ａ：（０．７６０９±０．１０６６）ｍｉｎ，Ｔ１／２ｂ：（１２．５６６７±３．７１３９）ｍｉｎ，Ｔ１／２ｃ：（１６２．５６５１±５０．６０３５）ｍｉｎ，Ｋ１２：（０．５１２３±０．１３１６）ｍｉｎ－１，Ｋ２１：（０．３２９８±０．０７３７）ｍｉｎ－１，Ｋ１３：（０．０７３９±０．０１８２）ｍｉｎ－１，Ｋ３１：（０．０１００±０．００３７）ｍｉｎ－１，Ｋ１０：（０．０７７４±０．０１６０）ｍｉｎ－１，Ｖｃ：（０．０４０４±０．００４４）Ｌ·ｋｇ－１，ＡＵＣ：（１６７９．７５８３±４８０．６０４５）ｍｇ·Ｌ－１·ｍｉｎ－１，ＣＬ（ｓ）：（０．００３１±０．０００８）Ｌ·ｋｇ－１·ｍｉｎ－１。结论芸香甙在兔体内的Ｃ－Ｔ变化符合三室开放模型；芸香甙在体内的分布、消除迅速。
Objective To study the pharmacokinetics of rutin in rabbits. Methods Routine intravenous rutin 5mg · kg-1, the use of fluorescence spectrophotometry at different times of plasma concentration. Application 3P87 Pharmacokinetics software program for computer data processing. Results The pharmacokinetic (C-T) equation for rutin was: C = 85.9789e-0.9044T + 34.5105e-0.0587T + 4.3838e-0.0046T. The main pharmacokinetic parameters of rutin were as follows: T1 / 2a: (0.7609 ± 0.1066) min, T1 / 2b: (12.5667 ± 3.7139) min, T1 / 2c: (162.5651 ± 50.6035) min, K12: (0.5123 ± 0.1316) min-1, K21: (0.3298 ± 0.0737) min-1, K13: (0.0739 ± 0.0182) min-1 , K31: (0.0100 ± 0.0037) min-1, K10: (0.0774 ± 0.0160) min-1 and Vc: (0.0404 ± 0.0044) L · kg- (1679.7583 ± 480.6045) mg · L-1 · min-1, CL (s): (0.0031 ± 0.0008) L · kg-1 · min-1. Conclusion Rutin in rabbit body C-T changes in line with the three-compartment open model; rutin distribution in the body, eliminate rapidly.