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自六十年代Marchioro和Starzl等人通过一系列实验研究,首次提出“肝营养因子”(HepatotrophicFactors)的概念以来,各国学者用不同的实验方法,在不同的研究领域中就这一问题做了大量的工作,使肝营养因子的本质,来源及作用渐被揭示,特别是胰岛素的肝营养作用不断被证实,从而开拓了肝脏病学研究的一个新领域。关于门脉血转流的研究早在1893年,俄国学者Hahn就发现门静脉血的转流将导致实验犬肝脏萎缩和脂肪变性;而脾静脉血的灌流则可减轻上述病变,但他们的研究结果一直未受到普遍的注意。
Since the concept of “HepatotrophicFactors” was firstly proposed by Marchioro and Starzl et al in a series of experimental studies in the 1960s, scholars of different countries used different experimental methods to do a lot of work on this issue in different fields The nature, origin and function of hepatic trophic factor are gradually revealed. In particular, the hepatic nutrition of insulin has been continuously confirmed, thus opening up a new field of hepatology research. As early as 1893, Russian scholar Hahn found that the diversion of portal vein blood lead to hepatic atrophy and steatosis in experimental dogs. However, the perfusion of splenic venous blood can reduce the above lesions. However, their findings Has not been the general attention.