患有炎症性疼痛的成年人,阿片样物质对其具有良好的止痛作用,且无副作用和耐药性。其机制可能是通过对存在于感觉神经末梢的阿片样物质受体作用而产生的,炎症时这种受体是上调的。有关阿片样物质对儿童患者的外周作用尚未见报道。有2例患有大疱性表皮松解症儿童局部应用吗啡凝胶进行止痛。因为急性炎症性疼痛是这种疾病的主要症状,有效止痛是临床的首要 Adults with inflammatory pain, opioids have a good analgesic effect, and no side effects and drug resistance. The mechanism may be through the presence of sensory nerve endings opioid receptors produced by the inflammation of the receptor is upregulated. Peripheral effects of opioids on pediatric patients have not been reported. In 2 children with epidermolysis bullosa, topical morphine gel was used for analgesia. Because acute inflammatory pain is a major symptom of this disease, effective analgesia is clinically important