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用ＰＣＲ检测了ＨＢＶ标志不同状态１０２例，均经肝活检诊断，其中慢性迂延性肝炎（ＣＰＨ）７４例，慢性活动性肝炎（ＣＡＨ）２１例，肝组织正常７例。结果：ＨＢｓＡｇ阳性率ＣＡＨ为８５．７％，显著高于ＣＰＨ４７．３％（Ｐ＜０．０１）；抗－ＨＢｓ阳性率ＣＰＨ为１８．９％，明显高于ＣＡＨ４．７％。ＰＣＲ血清ＨＢＶＤＮＡ总阳性率分别为ＣＰＨ８３．８％、ＣＡＨ８５．７％。在抗－ＨＢｅ阳性的血清ＨＢＶＤＮＡ检出率ＣＰＨ９０．５％，ＣＡＨ８５．７％。抗－ＨＢｓ阳性血清ＨＢＶＤＮＡ检出率ＣＰＨ为４４．４％，提示抗－ＨＢｅ和抗－ＨＢｓ阳性不仅不能代表ＨＢＶ复制停止或已被消除，而且肝脏仍可处于炎症状态。
102 cases of different signs of HBV were detected by PCR, all of them were diagnosed by liver biopsy. Among them, 74 cases were chronic prolonged chronic hepatitis (CPH), 21 cases were chronic active hepatitis (CAH) and 7 cases were normal liver tissue. Results: The positive rate of HBsAg was 85.7% for CAH, which was significantly higher than that for CPH47.3% (P <0.01). The positive rate of anti-HBs was 18.9%, which was significantly higher than that of CAH4.7%. The total positive rate of PCR HBVDNA was 83.8% of CPH and 85.7% of CAH. Anti-HBe positive serum HBVDNA detection rate of CPH90.5%, CAH85.7%. Anti-HBs positive serum HBVDNA detection rate was 44.4% CPH, suggesting that anti-HBe and anti-HBs positive not only can not stop the replication of HBV or has been eliminated, and the liver can still be in an inflammatory state.