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目的对比分析三阴性乳腺癌(TNBC)与非三阴性乳腺癌超声造影时间-强度曲线(TIC),初步探讨其产生差异的原因及临床应用价值。方法回顾性分析病理证实乳腺癌患者126例,TNBC组25例,非TNBC组101例,分别记录每个病灶内部及周边TIC曲线参数值,对各参数进行组内(同一病灶内部及周边)及组间(三阴组与非三阴组)比较,并对组间比较有差异的参数行ROC曲线分析,计算分界值。结果组内比较TNBC组仅病灶内部与周边始增时间差异有统计学意义(P<0.05),非TNBC组病灶内部与周边始增时间、达峰时间、峰值强度、增强强度差异均有统计学意义(P<0.05);组间比较TNBC组内部达峰时间及内部始峰时间差小于非TBNC组,TNBC组内部增强强度、内部上升支斜率、周边增强强度、周边曲线下面积均大于非TNBC组,两两比较差异有统计意学义(P<0.05);初步界定内部增强强度>16.8,内部上升支斜率>0.756,周边增强强度>18.45,周边曲线下面积>864.66时,病灶均倾向于提示TNBC可能。结论 TIC曲线定量分析可在某种程度上帮助术前筛查TNBC,有一定的临床应用价值。
Objective To compare and analyze the time-intensity curve of contrast-enhanced ultrasound (TIC) between triple-negative breast cancer (TNBC) and non-triple negative breast cancer (TCC) and to explore the causes and clinical value of the differences. Methods Totally 126 breast cancer patients, 25 TNBC patients and 101 non-TNBC patients were retrospectively analyzed. The parameters of TIC in each lesion were recorded, and the parameters of each lesion were recorded within the same lesion and in the periphery. (Sanyin group and non-Sanyin group) were compared. ROC curve analysis was performed to compare the differences between the groups, and the cut-off value was calculated. Results There were significant differences between the two groups (P> 0.05). There was statistical difference between the two groups in TNBC group (P <0.05) (P <0.05). The intra-peak time and internal peak time difference in TNBC group were less than those in non-TBNC group. The internal strength, internal slope, peripheral strength and area under TNBC in TNBC group were higher than those in non-TNBC group (P <0.05). The initial defined internal enhancement strength> 16.8, the internal rising branch slope> 0.756, the peripheral enhancement strength> 18.45, and the area under the peripheral curve> 864.66, the lesions tended to be suggestive TNBC possible. Conclusion TIC curve quantitative analysis can help preoperative screening of TNBC to a certain extent, and has certain clinical value.