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作者介绍了亚硝胺对各种不同种类的动物,包括灵长类动物在内,有广泛的致癌作用。因为这些化合物存在于环境中,有时浓度很高,并且在体内可由亚硝酸盐和胺形成,所以近年来对它们的致癌性及其代谢引起了广泛的兴趣。环状亚硝胺-NPYR存在于熟腌肉,加工肉,香料前混合物以及烟草的烟雾中。一种有关的化合物2(3-吡啶基)亚硝基吡咯烷(即N′-亚硝基去甲基尼古丁)是重要的烟草特异性致癌物。NPYR能诱发大鼠的肝细胞癌。当加肝微粒体时,这种坏状亚硝胺对大肠杆菌、鼠伤寒沙门氏菌也有致突
The authors describe a wide range of carcinogenic effects of nitrosamines to a variety of different species of animals, including primates. Since these compounds are present in the environment, sometimes in high concentrations, and can be formed from nitrites and amines in the body, their carcinogenicity and their metabolism have attracted a great deal of interest in recent years. Cyclic nitrosamines -NPYR is present in cooked bacon, processed meat, pre-fragrance mixtures and tobacco smoke. One related compound, 2 (3-pyridyl) nitrosopyrrolidine (ie, N’-nitroso-n-methyl nicotine) is an important tobacco-specific carcinogen. NPYR can induce hepatocellular carcinoma in rats. When liver microsomes, this bad nitrosamines Escherichia coli, Salmonella typhimurium also cause sudden