论文部分内容阅读
建立以人体细胞作为污染物的体外短期实验系统已成为环境毒理学研究的趋势之一。人胚肺成纤维细胞(HELF)的遗传性状接近体内正常细胞,且对外加作用因子比较敏感,已用于多种环境污染物和外源性化合物的毒性研究。该文综述了环境污染物中已知的致癌物和潜在致癌物、纳米颗粒以及大气颗粒物、香烟烟雾、烹调油烟等对人胚肺成纤维细胞的毒性及其作用机制,为深入研究环境污染物对人体健康的影响提供科学依据。
The establishment of an in vitro short-term experimental system using human cells as contaminants has become one of the trends of environmental toxicology research. Human embryonic lung fibroblast (HELF) genetic traits close to the normal cells in vivo, and more sensitive to external factors, has been used for a variety of environmental pollutants and exogenous compounds toxicity studies. This paper reviewed the carcinogenic and potential carcinogens, nanoparticles and atmospheric particulate matter, cigarette smoke, cooking fumes and other toxic effects on human embryo lung fibroblasts and its mechanism of action, in order to further study the environmental pollutants The impact on human health to provide a scientific basis.