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阐明肝纤维化或肝脏的疤痕反应一直是现今肝脏病学研究的主要热点,尤其是肝星状细胞(HSC)活化是肝纤维化发生、发展的中心环节,且其活化过程已成为详细了解肝纤维化发生的重要环节。然而,目前对肝纤维化为何会加快肝细胞癌发生了解尚不多。在正常和纤维化肝脏中。HSC是细胞外基质的主要来源细胞。在进展期,HSC经历一个“活化”或转化后,形成一种活跃增生、致纤维化和收缩的细胞类型。HSC活化是纤维化发生的中心事件。对这个过程分子机制的认识现已取得了很大
To clarify the liver fibrosis or liver scar response has been the focus of current liver disease research, in particular, hepatic stellate cells (HSC) activation is the occurrence and development of liver fibrosis, and its activation process has become a detailed understanding of the liver Fibrosis occurs an important part. However, at present, there is not much understanding on why liver fibrosis will accelerate the occurrence of hepatocellular carcinoma. In normal and fibrotic liver. HSC is the main source of extracellular matrix cells. In advanced stages, HSCs undergo an “activation” or transformation to form a cell type that is actively proliferating, fibrotic, and contractile. HSC activation is a central event in fibrosis. The understanding of the molecular mechanism of this process is now gaining a great deal