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用心脏超声及放射免疫法分别检测甲亢患者抗甲状腺素药物治疗前后与正常对照组的心脏舒张功能(Ⅱa-MVO、MaxRFV、PeakE、PeakA、E/A),心脏前后负荷(LVEDY、ESS),左室收缩力(ESS/LVESV)及血清T_3和血浆cAMP。结果显示:治疗前甲亢组与对照组比较,Ⅱa-MVO明显缩短,MaxRFV、PeakE、PeakA明显延长。甲亢组血浆cAMP、ⅡaMVO、MaxRFV、PcakE和E/A与血清T_3水平有显著的简单相关。血浆cAMP、Ⅱa-MVO、MaxRFV和PeakE与T_3有显著偏相关,但Peak与T_3之间偏相关系数小于年龄及前负荷与T_3之偏相关系数。甲亢组经平均180天抗甲状腺素治疗后,其左室舒张功能、血浆cAMP与治疗前比较有显著差异,而与对照组无差异。
Cardiac diastolic function (Ⅱa-MVO, MaxRFV, PeakE, PeakA, E / A), LVEDY (ESS), cardiac output before and after anti-thyroid hormone treatment were measured by echocardiography and radioimmunoassay Left ventricular contractile force (ESS / LVESV) and serum T_3 and plasma cAMP. The results showed that: before treatment, hyperthyroidism group compared with the control group, Ⅱ a-MVO significantly shortened, MaxRFV, PeakE, PeakA significantly prolonged. Hyperthyroidism plasma cAMP, Ⅱ aMVO, MaxRFV, PcakE and E / A and serum T_3 levels were significantly simple correlation. The plasma cAMP, Ⅱa-MVO, MaxRFV and PeakE were significantly correlated with T_3, but the partial correlation coefficient between Peak and T_3 was less than that between age and pre-load and T_3. Hyperthyroidism group by an average of 180 days of anti-thyroxine treatment, the left ventricular diastolic function, plasma cAMP and before treatment were significantly different, but no difference with the control group.