患者,男,4岁。安徽省宿县人。因生后反复呕吐,智能发育低下而于1985年12月5日来我院检查。吐呕非喷射性,每2～3天呕吐1～2次。吐出胃内容物。大便正常,不发热。家长诉说患儿生后即有眼球突出,头颅及手足畸形。患儿系第三胎、第三产,足月顺产,母孕期无特殊疾病及服药史。母乳喂养三个月后以奶粉人工喂养。2岁半才开始学会讲话,至今只能讲2～3个 Patient, male, 4 years old. Su County, Anhui Province. Due to repeated vomiting after birth, mental retardation and in December 5, 1985 to our hospital examination. Vomit non-jet, vomiting every 2 to 3 days 1 to 2 times. Spit stomach contents. Normal stool, no fever. Parents complain that children have prominent eye after birth, head and hand-foot deformities. Pediatric third-trimester, the third trimester, term full-term pregnancy, no special disease during pregnancy and medication history. Breastfeeding three months after artificial feeding with milk powder. Two and a half years old began to learn to speak, so far can only say 2 to 3