论文部分内容阅读
回顾性分析186例2型糖尿病患者血尿酸(SUA)水平,比较高尿酸血症组(HUA组)和正常血尿酸组(UA正常组)的性别、年龄、病程、体重指数(BMI)、平均动脉压(MAP)、血脂、糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、空腹血清胰岛素(FINS)、血尿酸(SUA)、胰岛素抵抗指数(HOMA-IR)、肌酐清除率(Ccr)等指标,并对血尿酸的影响因素进行多元逐步回归分析,比较病程为0-5年(A组)、5-10年(B组)、10-15年(C组)三组间的血尿酸水平。结果:HUA组的甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、FPG、FINS、SUA、HOMA-IR高于UA正常组(P<0.05);多元逐步回归分析显示,病程、BMI、TG、Hb A1c、Ccr和HOMA-IR是影响血尿酸的独立相关因素,其中Ccr和SUA呈负相关;不同病程组间的血尿酸水平有统计学差异,病程越长血尿酸水平越高。结论:2型糖尿病合并高尿酸血症与糖尿病病程的延长、肥胖、高甘油三酯、高血糖、肌酐清除率的下降及胰岛素抵抗密切相关。
A retrospective analysis of 186 cases of type 2 diabetes patients with serum uric acid (SUA) levels, hyperuricemia group (HUA group) and normal uric acid group (UA normal group) gender, age, duration, body mass index (BMI) (MAP), blood lipid, Hb A1c, FPG, FINS, SUA, HOMA-IR, Ccr and so on Index, and the influencing factors of serum uric acid were analyzed by multivariate stepwise regression analysis. The serum uric acid was compared between the three groups with disease duration of 0-5 years (group A), 5-10 years (group B), and 10-15 years (group C) Level. Results: TG, LDL-C, FPG, FINS, SUA and HOMA-IR in HUA group were higher than those in normal UA group (P <0.05). Multiple stepwise regression analysis showed that the duration , BMI, TG, Hb A1c, Ccr and HOMA-IR were independent correlative factors affecting serum uric acid, of which Ccr and SUA were negatively correlated; serum uric acid levels were significantly different between different course groups, the longer course of the disease serum uric acid level high. CONCLUSION: Type 2 diabetes with hyperuricemia is associated with prolonged duration of diabetes, obesity, high triglycerides, hyperglycemia, decreased creatinine clearance, and insulin resistance.