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目的调查新疆伊犁地区农村居住儿童媒介传播立克次体感染状况。方法 2012年8-11月选择伊犁州伊宁市、巩留县及昭苏县农村6~12岁儿童为调查对象,采集血液标本。采用WHO推荐的微量间接免疫荧光方法(m-IFA),对7种媒介传播立克次体进行血清Ig G抗体检测,比较每种立克次体抗体阳性率在3个调查点间及2个年龄组间的差异。结果本次调查共检测7种立克次体Ig G抗体,平均每种病原体检测血清246份,共检测血清1 722份。结果显示蜱传西伯利亚立克次体、嗜单核细胞埃立克体、嗜吞噬细胞无形体、贝氏苛柯斯体人群抗体阳性率分别为37.4%(92/246)、29.3%(72/246)、15.4%(38/246)和12.6%(31/246)。蚤传汉赛巴尔通体、莫氏立克次体及螨传恙虫病东方体抗体阳性率分别为15.8%(39/246)、5.7%(14/246)和11.8%(29/246)。同一病原体在男女性别、3个调查点及2个年龄组间阳性率差异无统计学意义(P>0.05)。结论新疆伊犁地区农村儿童普遍存在媒介传播立克次体感染状况,加强临床诊断及鉴别诊断、对急性不明原因发热儿童在高度怀疑立克次体感染情况下,经验性抗立克次体治疗具有重要临床意义。
Objective To investigate the status of transmission of Rickettsia among rural children living in Yili, Xinjiang. Methods From August to November 2012, blood samples were collected from 6 to 12-year-old children in rural Yining, Gongliu County and Zhaosu County, Yili Prefecture. Serum Ig G antibody was detected in seven kinds of vector-transmitted rickettsiae by micro indirect immunofluorescence assay (m-IFA) recommended by the WHO. The positive rate of each rickettsial antibody was compared among three survey sites and two Differences between age groups. Results A total of 7 Rickettsia Ig G antibodies were detected in this investigation. The mean of 246 serum samples was detected for each pathogen, and 1722 serum samples were detected. The results showed that the antibody positive rates of tick-transmitted Siberian rickettsia, eotaxin monocytic, phagocytosis of phagocytic phagocytes, and Berserker were 37.4% (92/246) and 29.3% (72 / 246), 15.4% (38/246) and 12.6% (31/246). The positive rates of Fabryncarpus, Mottling and Mitechia tsutsugamushi were 15.8% (39/246), 5.7% (14/246) and 11.8% (29/246) respectively. There was no significant difference in the positive rate of the same pathogen between male and female, 3 survey points and 2 age groups (P> 0.05). Conclusion In rural Yilu, there is widespread transmission of Rickettsia among rural children in China. The diagnosis and differential diagnosis of Rickettsia in rural children with acute unexplained fever are more likely to occur in children with highly suspected Rickettsia. Important clinical significance.