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目的了解代谢综合征(MS)患者中内脂素水平的变化,并探讨内脂素与及各组分的相关性。方法从2011年12月到2012年2月在延边大学附属医院健康体检中心参与健康体检的20岁以上成年人1 500名中选取检测指标完整的1 013名作为研究对象,测定血糖、血脂、内脂素等生化指标,并测量身高、体重及血压。根据中华糖尿病分会2004年关于代谢综合征(MS)的建议分代谢综合征组(n=152)和正常对照组(n=861)。分析内脂素与MS及组分的相关性。结果 MS组内脂素水平[(2.12±0.01)pg/ml]高于对照组[(2.02±0.01)pg/ml],差异有统计学意义(F=84.462,P<0.001)。内脂素与收缩压(SBP)、舒张压(DBP)、体质指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)和血尿酸(UA)呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关。随着MS组分数目的增加,内脂素水平也增加(P<0.01)。logistic回归分析结果显示,高血压、BMI、HDL-C、TG、FPG、内脂素是MS的影响因素。结论内脂素在MS的发生发展中起一定的作用。
Objective To understand the changes of visfatin in patients with metabolic syndrome (MS) and to explore the correlation between visfatin and its components. Methods From December 2011 to February 2012, 1 013 full-scale adult children over 20 years of age participating in physical examination at the Health Check-up Center of Yanbian University Affiliated Hospital were enrolled as test subjects, and blood glucose, blood lipid, Lipids and other biochemical indicators, and measure height, weight and blood pressure. According to the 2004 China Diabetes Branch Metabolic Syndrome (MS) recommendations sub-metabolic syndrome group (n = 152) and the normal control group (n = 861). The correlation between visfatin and MS and its components was analyzed. Results The level of visfatin in MS group [(2.12 ± 0.01) pg / ml] was higher than that in control group [(2.02 ± 0.01) pg / ml], the difference was statistically significant (F = 84.462, P <0.001). SBP, DBP, TC, TC, TG, LDL-C, FPG ) And serum uric acid (UA) were positively correlated and negatively correlated with high density lipoprotein cholesterol (HDL-C). As the number of MS components increased, the level of visfatin increased (P <0.01). Logistic regression analysis showed that hypertension, BMI, HDL-C, TG, FPG and visfatin were the influencing factors of MS. Conclusion Visfatin plays a role in the development of MS.