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目的探讨检测超敏C反应蛋白(hs-CRP)和尿微量白蛋白(mALB)对糖尿病性肾病(DN)患者诊断的临床意义。方法将我院于2012年11月至2013年10月收治的80例糖尿病患者分为糖尿病组48例和DN组32例,并选择30例健康体检者作为健康对照组,分别测定各组患者的hs-CRP和mALB水平。结果糖尿病组患者的hs-CRP与mALB水平与健康对照组比较,差异均有统计学意义(P<0.05);DN组患者的hs-CRP与mALB水平与健康对照组比较,差异均有统计学意义(P<0.01);DN组患者的hs-CRP与mALB水平与糖尿病组比较,差异亦均有统计学意义(P<0.01)。结论hs-CRP和mALB水平可反映DN患者的病变程度,可作为DN早期诊断的灵敏性指标。
Objective To investigate the clinical significance of detecting hs-CRP and mALB in the diagnosis of diabetic nephropathy (DN). Methods Eighty diabetic patients admitted to our hospital from November 2012 to October 2013 were divided into diabetic group (48 cases) and DN group (32 cases), and 30 healthy subjects were selected as healthy control group. The patients in each group hs-CRP and mALB levels. Results The hs-CRP and mALB levels in diabetic patients were significantly different from those in healthy controls (P <0.05). The levels of hs-CRP and mALB in DN patients were significantly lower than those in healthy controls (P <0.01). There was also a significant difference in hs-CRP and mALB between DN group and diabetic group (P <0.01). Conclusions The levels of hs-CRP and mALB can reflect the degree of pathological changes in patients with DN, and can be used as a sensitive indicator of early diagnosis of DN.