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目的 :探讨中西医结合治疗小儿肺炎及防治并发症的作用。方法 :选择小儿肺炎 167例 ,随机分为两组 ,治疗组给予固本清热化瘀方剂———金宁益康口服液 10ml ,每日 3次 ,<5岁 10ml ,每日 2次 ;对照组给予甘草合剂 ,1ml/岁 ,每日 3次。用药后分别记录病人的症状、体征、X线。并于用药前和服药后 3d抽查血清白介素 2(IL 2 ) ,12d抽查血清肿瘤坏死因子α(TNF α)、T淋巴细胞亚群、免疫球蛋白 ,补体C3 、C4。结果 :治疗组症状、体征消失天数、异常胸片阴转率均明显优于对照组 ,差异有显著意义 (P <0 0 5～ 0 0 0 1) ,IL 2、C3 、C4、T淋巴细胞亚群两组差异亦有显著意义 (P <0 0 5～ 0 0 0 1)。而TNF α治疗组治疗后明显低于对照组 ,两组差异有显著意义 (P <0 0 1)。治疗组无发生并发症病例 ,而对照组 3例发生急性心力衰竭 ,1例中毒性脑病。未见本方药有明显副作用。结论 :中西医结合治疗小儿肺炎及防治并发症是可靠有效的方法。
Objective: To explore the role of Integrative Medicine in the treatment of pneumonia in children and prevention and treatment of complications. Methods: One hundred and sixty-seven children with pneumonia were selected and divided into two groups randomly. The treatment group received 10ml of Guben Qingre Huayu oral solution (Jinning Yikang oral solution, 3 times a day, 10ml of <5 years old, twice daily) Group given licorice mixture, 1ml / year, 3 times a day. After treatment were recorded the patient’s symptoms, signs, X-ray. Serum interleukin - 2 (IL - 2) levels were determined before treatment and 3 days after medication. Serum levels of tumor necrosis factor alpha (TNFa), T lymphocyte subsets, immunoglobulins, complement C3 and C4 were determined 12 days later. Results: There were significant differences between the treatment group and the control group in the number of days of symptom disappearance, the number of signs disappeared and the abnormal chest radiograph rate (P <0.05-0.01), and the levels of IL 2, C3, C4, T lymphocytes Subgroup differences between the two groups also have significant significance (P <0 0 5 ~ 0 0 0 1). However, TNFα treatment group was significantly lower than the control group after treatment, the difference was significant (P <0.01). No complications occurred in the treatment group, while 3 cases in the control group had acute heart failure and 1 case of toxic encephalopathy. No side effects of this prescription have been observed. Conclusion: Integrative Medicine in children with pneumonia and prevention and treatment of complications is a reliable and effective method.