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目的观察氟伐他汀对糖尿病大鼠心功能及心室重塑的影响。方法给予SD大鼠ip链脲佐菌素制备糖尿病模型。观察氟伐他汀及联合胰岛素治疗对糖尿病大鼠的体重、血糖、24h代谢、心功能及心室重塑的影响。结果氟伐他汀对糖尿病大鼠的体重、血糖及24h代谢情况无明显影响(P>0.05),可改善糖尿病大鼠的心电图、心功能及心室重塑指标(P<0.05)。结论氟伐他汀对糖尿病大鼠心肌病变具有保护作用。
Objective To observe the effect of fluvastatin on cardiac function and ventricular remodeling in diabetic rats. Methods SD rats were given ip streptozotocin to prepare diabetic model. To observe the effects of fluvastatin and insulin therapy on body weight, blood glucose, 24h metabolism, cardiac function and ventricular remodeling in diabetic rats. Results Fluvastatin had no effect on the body weight, blood glucose and 24h metabolism of diabetic rats (P> 0.05), and could improve the ECG, cardiac function and ventricular remodeling index in diabetic rats (P <0.05). Conclusion Fluvastatin has a protective effect on myocardial lesions in diabetic rats.