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目的探讨泌乳素(PRL)水平变化与内分泌失调性不孕症的相关关系。方法回顾性分析该院诊治的98例不孕症妇女(不孕组)的内分泌检测结果资料,与同期正常生育期妇女100例(对照组)的内分泌检测结果进行对比研究,同时将不孕组根据月经周期是否紊乱分成月经紊乱组(66例)和月经正常组(32例),并对PRL、卵泡刺激素(FSH)、促黄体激素(LH)、雌二醇(E2)和睾酮(T)进行比较。结果不孕组PRL(19.42±2.18)U/L、FSH(19.83±4.02)U/L、LH(14.29±2.14)U/L显著高于对照组〔分别为(5.31±0.92)U/L、(6.47±1.57)U/L、(10.44±1.28)U/L〕,差异有统计学意义(P<0.05);E2(71.32±17.84)pg/ml、T(47.29±6.28)ng/dl显著低于对照组〔分别为(164.9±34.91)pg/ml、(60.33±7.24)ng/dl〕,差异有统计学意义(P<0.05)。PRL与FSH呈显著的正相关(r=0.518,P=0.000);PRL与LH呈显著的正相关(r=0.531,P=0.000);PRL与E2呈显著的负相关(r=-0.551,P=0.000);PRL与T无相关性(r=0.052,P=0.079)。月经紊乱组PRL(17.14±2.11)U/L、FSH(20.87±3.51)U/L、LH(15.17±1.76)U/L显著高于月经正常组〔分别为(15.17±2.09)U/L、(18.96±3.72)U/L、(13.25±1.89)U/L〕,差异有统计学意义(P<0.05)。月经紊乱组和月经正常组E2、T值差异无统计学意义(P>0.05)。结论内分泌失调性不孕症患者的PRL水平较正常生育妇女显著地升高,同时PRL与FSH、LH、E2的水平变化具有相关性。
Objective To investigate the relationship between the changes of prolactin (PRL) levels and endocrine disorders infertility. Methods The data of endocrine tests of 98 infertile women (infertility group) diagnosed and treated in this hospital were retrospectively analyzed. The results of endocrine tests were compared with those of 100 normal women (control group) during the same period of pregnancy. At the same time, According to whether the menstrual cycle was disturbed or not, the patients were divided into menstrual disorder group (66 cases) and normal menstruation group (32 cases). The levels of PRL, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol )Compare. Results The levels of PRL in the infertility group (19.42 ± 2.18) U / L, FSH (19.83 ± 4.02) U / L, and LH (14.29 ± 2.14) U / L were significantly higher than those in the control group (5.31 ± 0.92 U / L, (6.47 ± 1.57) U / L, (10.44 ± 1.28) U / L〕 (P <0.05); E2 (71.32 ± 17.84) pg / ml and T (47.29 ± 6.28) ng / dl were significantly (164.9 ± 34.91) pg / ml, (60.33 ± 7.24) ng / dl respectively), the difference was statistically significant (P <0.05). There was a significant positive correlation between PRL and FSH (r = 0.518, P = 0.000). There was a significant positive correlation between PRL and LH (r = 0.531, P = 0.000) P = 0.000). There was no correlation between PRL and T (r = 0.052, P = 0.079). In the menstrual disturbance group, the PRL (17.14 ± 2.11) U / L, FSH (20.87 ± 3.51) U / L and LH (15.17 ± 1.76) U / L were significantly higher than those in the normal menstruation group (15.17 ± 2.09 U / L, (18.96 ± 3.72) U / L, (13.25 ± 1.89) U / L〕, the difference was statistically significant (P <0.05). Menstrual disorders group and normal menstruation E2, T value was no significant difference (P> 0.05). Conclusions PRL levels in patients with endocrine disorders infertility were significantly higher than those in normal fertility women, meanwhile PRL was correlated with the levels of FSH, LH and E2.