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２４只雄性大鼠以３ｍｇ／ｋｇ叠氮化钠作腹腔注射，染毒，每日６次，每次间隔０．５ｈ，连续４ｄ直至中毒。神经病理检查结果表明，叠氮化钠对脑的损伤呈双侧对称性，主要是尾－壳核。光镜下可见神经元胞浆深染，核固缩，神经纤维束疏松肿胀，重者呈网眼状。电镜下早期可见神经元胞浆疏松，继而固缩，核染色质积聚，细胞周围可见肿胀的突起。神经纤维、胶质细胞和血管也出现病变。同时用大鼠建立了一个叠氮化钠引起脑内尾－壳核损伤的动物模型，以用于中毒机理研究。
Twenty-four male rats were injected intraperitoneally with 3 mg / kg sodium azide and exposed to 6 times a day for 0.5 h each for 4 days until intoxication. Neuropathological examination showed that sodium azide bilateral symmetry of brain damage, mainly tail-shell nucleus. Light microscopy shows neuronal cytoplasm deep staining, nuclear pyknosis, nerve fiber bundle loose swelling, severe were mesh-like. Electron microscope showed early neuronal cytoplasm loose, then shrinkage, nuclear chromatin accumulation, visible swelling around the cell processes. Nerve fibers, glial cells and blood vessels also appear lesions. At the same time, an animal model of cerebral sodium caudate-putamen injury induced by sodium azide was established for the study of mechanism of poisoning.