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乙型肝炎病毒(HBV)缺乏容许性组织培养系统,妨碍了对病毒基因产物的研究,直到最近,HBsAg 的唯一来源只是 HBV 慢性携带者或整合有HBV DNA的人体肝癌细胞株PLc/PRF/:。重组DNA技术开辟了构造嵌合病毒体的前景,从而使llBv在本身或其他动物病毒的启动一子控制下表达
The lack of an allowable tissue culture system for Hepatitis B virus (HBV) has hindered the investigation of viral gene products. Until recently, the only source of HBsAg was HBV chronic carriers or human hepatocellular carcinoma cell lines PLc / PRF / . Recombinant DNA technology opens up the prospect of constructing chimeric virions so that llBv is expressed under the control of a promoter of itself or other animal viruses