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目的:探讨13C呼气试验对轮状病毒性腹泻继发乳糖酶缺乏的诊断价值及其临床意义。方法:将13C-乳糖加入到100 mL温水中口服,并开始计时,于30,60,90,120,150,180 min呼出气体各100 mL,以时间(min)为横坐标,呼气13CO2百分含量为纵坐标,绘制曲线,计算曲线下面积即为3 h累积呼出量。20%~30%为正常范围,<20%提示乳糖不耐受,>30%为乳糖酶补充过量。结果:175例腹泻患儿,13C呼气试验测定阳性125例(71.43%),轮状病毒阳性组63例患儿,其中13C呼气试验检测阳性54例(85.71%),轮状病毒阴性对照组112例,其中13C呼气试验检测阳性71例(63.39%)。结论:轮状病毒性肠炎继发乳糖不耐受症的发病率高于其他腹泻病,13C呼气试验无损伤,且方法可靠、特异、简单,对诊断乳糖不耐受具有重要意义。
Objective: To investigate the diagnostic value of 13C breath test for secondary lactase deficiency in rotavirus diarrhea and its clinical significance. Methods: 13C-lactose was added orally to 100 mL of warm water, and the time was counted. Each 100 mL of exhaled gas was taken at 30, 60, 90, 120, 150 and 180 min. The time (min) was taken as the abscissa and the expired 13CO2 percentage was taken as the ordinate. Draw the curve, calculate the area under the curve is 3 h cumulative exhaled volume. 20% to 30% of the normal range, <20% suggestive of lactose intolerance,> 30% of the excess lactase. Results: Among 175 cases of diarrhea, 125 cases (71.43%) were positive in 13C breath test and 63 cases in rotavirus positive group (54.7%, 13.7%). Rotavirus negative control The group consisted of 112 patients, of which 13C was positive in 71 breath test (63.39%). Conclusion: The incidence of lactose intolerance secondary to rotavirus enteritis is higher than that of other diarrheal diseases. The 13C breath test has no injury and the method is reliable, specific and simple, which is of great significance for the diagnosis of lactose intolerance.