肾小球基膜(GBM)是肾脏滤过屏障的重要组成成分,既往研究发现,Alport综合征(AS)、Good pasture(GP)综合征和糖尿病肾病等肾脏疾病存在GBM异常。为此,人们对GBM的化学及生物特性进行了大量研究,以探讨这些疾病的发病机制。经过多年不懈研究,人们发现了Ⅳ型胶原6条α链的存在并认 Glomerular basement membrane (GBM) is an important component of the renal filtration barrier. Previous studies have found that GBM abnormalities exist in kidney diseases such as Alport syndrome (AS), Good pasture (GP) syndrome and diabetic nephropathy. To this end, a large number of studies have been conducted on the chemical and biological properties of GBM to explore the pathogenesis of these diseases. After many years of unremitting research, people have found the presence of type IV collagen α chain and recognized