辨证分型联合西药治疗消化性溃疡随机平行对照研究

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[目的]观察辨证分型联合西药治疗消化性溃疡疗效。[方法]使用随机平行对照方法,将114例门诊患者按就诊顺序号法简单随机分为两组。忌食生冷、油腻、辛辣、腥味的食物,按时休息和进餐。对照组57例奥美拉唑,20mg/次,2次/d;克拉霉素,0.25g/次,2次/d;阿莫西林,0.5g/次,3次/d。治疗组57例辨证分型,肝胃不和,疏肝和胃(柴胡、陈皮、半夏制、元胡各9g,枳实6g,白芍12g、乌贼骨18g,生甘草6g);脾胃湿热,清热化湿(黄连6g,姜半夏、白术、木香、陈皮、佩兰各9g,土茯苓15g,桃仁6g);气滞血瘀,祛瘀止痛(蒲黄、赤芍、元胡、川楝子、乌贼骨15g,侧柏叶12g,三七分二次冲服3g,生甘草6g);脾胃虚寒,温胃健脾(黄芪炙、茯苓各15g,桂枝、干姜、甘草炙、元胡、金铃子、吴茱萸各9g,白芍、白术各12g,大枣四枚);1剂/d,水煎400m L,早晚口服,200m L/次;西药治疗同对照组。连续治疗14d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈31例,有效24例,无效2例,总有效率96.49%。对照组痊愈23例,有效25例,无效9例,总有效率84.21%。治疗组疗效优于对照组(P<0.05)。[结论]辨证分型联合西药治疗消化性溃疡疗效满意,无严重不良反应,值得推广。 [Objective] To observe the effect of syndrome differentiation and western medicine in treating peptic ulcer. [Methods] Using randomized parallel control method, 114 outpatients were randomly divided into two groups according to the sequence number of visiting doctor. Eat cold, greasy, spicy, fishy food, rest and meal on time. Control group of 57 cases of omeprazole, 20mg / time, 2 times / d; clarithromycin, 0.25g / time, 2 times / d; amoxicillin, 0.5g / time, 3 times / d. 57 cases of treatment group syndrome differentiation, liver and stomach, liver and stomach (Bupleurum, Citrus, Pinellia, Yuanhu 9g, citrus aurantium 6g, white peony root 12g, cuttlefish bone 18g, raw licorice 6g); spleen and stomach Dampness, heat dampness (Coptis 6g, ginger Pinellia, Atractylodes, woody, dried tangerine peel, Perrin each 9g, soil Poria 15g, peach kernel 6g); qi stagnation, blood stasis and pain (Puhuang, red peony root, Child, cuttlefish bone 15g, Arborvitae leaf 12g, berberine sub-Chonggong 3g, raw licorice 6g); spleen Deficiency, Wenwei Jianpi (Astragalus Sunburn, Poria 15g, Guizhi, ginger, licorice Sunburn, Yuan 1g / d, Decoction 400m L, morning and evening oral, 200m L / time; Western medicine treatment with the control group. Continuous treatment 14d for a course of treatment. Observed clinical symptoms, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group cured 31 cases, effective in 24 cases, 2 cases, the total effective rate was 96.49%. In the control group, 23 cases were cured, 25 cases were effective and 9 cases were ineffective. The total effective rate was 84.21%. The treatment group was better than the control group (P <0.05). [Conclusion] Syndrome differentiation combined with Western medicine is effective in treating peptic ulcer without serious adverse reactions and is worth promoting.
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