冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease,CAD),是指因冠状动脉狭窄或阻塞,造成心肌缺血、缺氧或坏死而引起的心脏病,是危害中老年人健康乃至生命的常见病之一。CAD作为一种复杂疾病,是由多个微效基因与环境因素长期相互作用所致。随着分子生物学的发展,从基因水平研究CAD发病机制己成为近几年的研究热点,许多 Coronary atherosclerotic heart disease (CAD) refers to heart disease caused by myocardial ischemia, hypoxia or necrosis due to stenosis or obstruction of the coronary arteries and is endangering the health and even life of the elderly One of the common diseases. As a complex disease, CAD is caused by the long-term interaction between multiple microsatellites and environmental factors. With the development of molecular biology, studying the pathogenesis of CAD from the genetic level has become a research hotspot in recent years. Many