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目的:分析HPVDNA分型与负荷量,探讨新疆地区HPV感染与宫颈病变的关系。方法:选取2008年9月～2009年8月于新疆肿瘤医院因宫颈病变就诊的144例患者临床资料进行统计分析,每一病例同时采用导流杂交基因芯片技术(HybriMax)和第二代杂交捕获(HC-Ⅱ)方法检测HPVDNA,观察HPV分型和负荷量与宫颈癌及其前期病变的关系。结果:144例患者最终组织病理学诊断为慢性宫颈炎21例、CINⅠ21例、CINⅡ～Ⅲ50例、宫颈癌52例。4组宫颈病变的HPV分型和负荷量分别与宫颈病变程度呈正相关;HPV多重感染与其负荷量值无关。结论:①HPV感染与宫颈癌及其前期病变存在明显相关性;②HPV检测阴性者仍有致病可能;③检测HPV对宫颈病变有良好的预见作用。
OBJECTIVE: To analyze the genotyping and load of HPVDNA to explore the relationship between HPV infection and cervical lesions in Xinjiang. Methods: The clinical data of 144 patients with cervical lesions treated in Xinjiang Cancer Hospital from September 2008 to August 2009 were statistically analyzed. In each case, both HybriMax and second generation hybridization capture (HC-Ⅱ) method to detect HPVDNA, observe the HPV type and load and the relationship between cervical cancer and its early lesions. Results: The histopathological diagnosis of 21 patients with chronic cervicitis was performed in 144 patients. There were 21 cases of CINⅠ, 50 cases of CINⅡ ~ Ⅲ and 52 cases of cervical cancer. The HPV type and load of 4 groups of cervical lesions were positively correlated with the degree of cervical lesions respectively; HPV multiple infection had no relation with the load. Conclusions: ①PV infection is closely related to cervical cancer and its precancerous lesions; ②HPV test negative may still have pathogenicity; ③ HPV test has a good predictive effect on cervical lesions.