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本文报告Aztreonam对503株致病菌(包括81株多重耐药菌)的体外抗菌活性,并与其它7种抗生素进行了比较。结果显示,Aztreonam对革兰氏阳性球菌均不敏感,但对革兰氏阴性菌具有强大抗菌活性。对肠杆菌科的各种细菌(除枸橼酸杆菌外),MIC_(90) 均≤1μg/ml,抑菌率均在90%以上。本品的抗菌作用与第三代头孢菌素和Imipenem接近或略优,而明显优于Moxalactam、哌拉西林和庆大霉素。本品对枸橼酸杆菌中度敏感;对绿脓杆菌作用良好,仅次于Ceftazidine和Imipenem。在浓度为8μg/ml时,可抑制77.8%的绿脓杆菌。不动杆菌仅对Imipenem敏感。大多数菌株的MIC与MBC无显著差别。同时还测定了Aztreonam对81株多重耐药菌的抗菌作用,其中只有13株菌的MIC大于8μg/ml,总抑菌率为84.0%。本研究为Aztreonam的临床应用提供了参考。
This article reports the in vitro antibacterial activity of Aztreonam against 503 pathogenic bacteria (including 81 multidrug-resistant bacteria) and compares it with seven other antibiotics. The results showed that Aztreonam is not sensitive to Gram-positive cocci, but has strong antibacterial activity against Gram-negative bacteria. For Enterobacteriaceae various bacteria (except Citrobacter outside), MIC_ (90) were ≤ 1μg / ml, antibacterial rates were above 90%. The antimicrobial effect of this product is close to or slightly superior to that of the third generation cephalosporins and Imipenem, but obviously superior to Moxalactam, piperacillin and gentamicin. This product is moderately sensitive to Citrobacter; Pseudomonas aeruginosa good effect, second only to Ceftazidine and Imipenem. At a concentration of 8 μg / ml, 77.8% of Pseudomonas aeruginosa was inhibited. Acinetobacter is only sensitive to Imipenem. MIC of most strains and MBC no significant difference. The antibacterial activity of Aztreonam on 81 multidrug-resistant bacteria was also determined. Among them, only 13 strains had a MIC greater than 8μg / ml and a total inhibitory rate of 84.0%. This study provides a reference for the clinical application of Aztreonam.