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目的观察白介素-Ⅱ联合顺铂治疗恶性胸腔积液的临床效果。方法本组64随机分为治疗组与对照组;均行胸腔细管闭式引流后,治疗组灌注入白介素-Ⅱ、顺铂和地塞米松;对照组灌注顺铂和地塞米松。10 d次/,最多不超过3次。结果治疗组和对照组有效率分别为84.27%和53.12%;两组差异有统计学意义(P<0.05)。结论胸腔内注入白介素-Ⅱ联合顺铂治疗恶性胸腔积液效果好,毒副作用小等优点。
Objective To observe the clinical effect of interleukin-Ⅱ combined with cisplatin in the treatment of malignant pleural effusion. Methods The 64 cases were randomly divided into treatment group and control group. After closed drainage of thoracic canaliculus, the treatment group was infused with interleukin-Ⅱ, cisplatin and dexamethasone; the control group was infused with cisplatin and dexamethasone. 10 d times /, up to no more than 3 times. Results The effective rates of the treatment group and the control group were 84.27% and 53.12% respectively. There was significant difference between the two groups (P <0.05). Conclusion Intracranial injection of interleukin-Ⅱ combined with cisplatin is effective in treating malignant pleural effusions with small toxic and side effects.