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[目的]探讨尿微量白蛋白(mALB)、β2-微球蛋白(β2-MG)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)对糖尿病肾病(DN)的早期诊断价值。[方法]采用免疫比浊法等分别检测128例非胰岛素依赖型糖尿病(NIDDM)患者及50例健康体检者晨尿mALB、β2-MG、NAG含量。[结果]NIDDM患者尿各项指标均较对照组增高(P﹤0.01);mALB阳性率32.8%,β2-MG阳性率25.8%、NAG阳性率为37.5%,三者比较差异无统计学意义(P﹥0.05)。单项检测阳性率较低,但mALB、β2-MG、NAG三项联合检测阳性率可达68.8%,灵敏度显著提高。[结论]尿mALB、β2-MG、NAG三项联合检测能更灵敏地发现糖尿病肾病的早期损害,为临床诊断提供更可靠的指标。
[Objective] To investigate the early diagnostic value of urinary microalbumin (mALB), β2-microglobulin (β2-MG) and N-acetyl-β-D glucosaminidase (NAG) in diabetic nephropathy (DN). [Method] The contents of mALB, β2-MG and NAG in morning urine of 128 non-insulin dependent diabetes mellitus patients and 50 healthy volunteers were detected by immunoturbidimetry. [Result] The indexes of urine of patients with NIDDM were higher than that of the control group (P <0.01). The positive rate of mALB was 32.8%, the positive rate of β2-MG was 25.8%, and the positive rate of NAG was 37.5%. There was no significant difference among the three P> 0.05). The positive rate of single detection was low, but the positive rate of mALB, β2-MG and NAG was 68.8%, and the sensitivity was significantly increased. [Conclusion] The combination of urinary mALB, β2-MG and NAG can detect the early damage of diabetic nephropathy more sensitively and provide more reliable indexes for clinical diagnosis.