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目的:观察经验方肺络清方联合支气管动脉介入化疗治疗晚期非小细胞肺癌的临床疗效。方法:应用随机平行对照方法,将60例住院患者随机分为对照组和观察组,每组30例。两组均采用支气管动脉介入化疗。观察组在对照组基础上加肺络清方中药汤剂内服。观察近期疗效、生活质量、中医症状疗效改善、不良反应以及远期疗效等指标。结果:两组患者近期疗效观察组优于对照组,但差异无统计学意义(P>0.05);观察组的生活质量改善和中医症状疗效均好于对照组,且差异有统计学意义(P<0.05);在不良反应发生方面,观察组对白细胞减少和血小板减少均有改善,和对照组相比差异有统计学意义(P<0.05),但在ALT升高上两组无统计学差异(P>0.05);观察组远期生存率上相比对照组更有优势,2年生存率与对照组相比,差异显著(P<0.05)。结论:肺络清方联合支气管动脉介入化疗治疗晚期非小细胞肺癌,可提升患者生活质量,减少化疗不良反应,增加患者远期生存率,值得推广应用。
OBJECTIVE: To observe the clinical efficacy of “Xiaofanshulian Fang combined with bronchial artery interventional chemotherapy” in the treatment of advanced non-small cell lung cancer. Methods: Sixty hospitalized patients were randomly divided into control group and observation group with 30 cases in each group. Bronchial artery interventional chemotherapy was used in both groups. Observation group in the control group based on the lungs and Qing Fang Chinese medicine decoction orally. Observation of short-term efficacy, quality of life, improvement of symptoms and signs of traditional Chinese medicine, adverse reactions and long-term efficacy and other indicators. Results: The short-term effect observation group was better than the control group, but the difference was not statistically significant (P> 0.05); the quality of life and TCM symptoms in the observation group were better than those in the control group (P <0.05). In the aspect of adverse reactions, the observation group had an improvement in leukopenia and thrombocytopenia, which was significantly different from the control group (P <0.05), but there was no significant difference in the ALT between the two groups (P> 0.05). The long-term survival rate of the observation group was superior to that of the control group. The 2-year survival rate was significantly different from that of the control group (P <0.05). Conclusion: The treatment of advanced non-small cell lung cancer with pulmonary colorectal cancer combined with bronchial artery chemotherapy can improve the quality of life of patients, reduce the adverse reaction of chemotherapy and increase the long-term survival rate of patients, which is worth popularizing and applying.