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目的:探讨乳腺浸润性导管癌中ER、PR和C-erbB-2的表达,并分析其相关性。方法:应用免疫组化方法,检测60例乳腺浸润性导管癌患者中ER、PR和C-erbB-2的表达情况。结果:ER、PR和C-erbB-2的阳性表达率分别为58.3%(35/60)、41.7%(25/60)和40.0%(24/60);ER与PR表达之间差异有统计学意义(P<0.05);ER与C-erbB-2表达之间差异无统计学意义(P>0.05);PR与C-erbB-2表达之间差异无统计学意义(P>0.05)。结论:C-erbB-2和ER、PR可能是乳腺癌预后指标的独立因子,但C-erbB-2表达与ER、PR关系有待研究。ER、PR在乳腺癌中的表达有相关性。
OBJECTIVE: To investigate the expression of ER, PR and C-erbB-2 in invasive ductal carcinoma of breast and to analyze their correlation. Methods: The expressions of ER, PR and C-erbB-2 in 60 patients with invasive ductal carcinoma of the breast were detected by immunohistochemistry. Results: The positive rates of ER, PR and C-erbB-2 were 58.3% (35/60), 41.7% (25/60) and 40.0% (24/60), respectively. The difference between ER and PR expression was statistically significant (P <0.05). There was no significant difference between ER and C-erbB-2 expression (P> 0.05). There was no significant difference between PR and C-erbB-2 expression (P> 0.05). Conclusion: C-erbB-2 and ER, PR may be independent prognostic factors in breast cancer. However, the relationship between C-erbB-2 expression and ER and PR remains to be studied. ER, PR expression in breast cancer have a correlation.